Adjunctive use of plasma rich in growth factors for improving alveolar socket healing. A systematic review
Journal of Evidence Based Dental Practice
Available online 26 November 2018
Abstract
Purpose
The
purpose of this study was to determine if the adjunctive use of plasma
rich in growth factors in post-extraction sites could be beneficial in
terms of hard/soft tissue healing and patient’s comfort.
Materials and Methods
An
electronic search was performed on MEDLINE, EMBASE, Scopus, and
CENTRAL. Only controlled clinical trials or randomized clinical trials
that used plasma rich in growth factors in the test group were included.
The primary outcomes were: pain assessment, complications and adverse
events; secondary outcomes were hard tissue healing, bone remodelling,
soft tissue healing.
Results
Eight
comparative studies (5 RCTs) were included. Four studies had a
split-mouth design. 614 teeth were extracted in 338 patients. Only
qualitative analysis could be done. Postoperative pain and the incidence
of complications like alveolar osteitis was consistently lower in the
test group. Hard tissue healing, evaluated by clinical, radiographic,
histological and histomorphometric technique showed results
significantly better for the test group in almost all studies. Better
epithelization, keratinized tissue thickness and healing score were also
reported.
Conclusion
Plasma
rich in growth factors may bring advantages in some relevant clinical
and radiographic outcomes following tooth extraction, such as bone
density and soft tissue healing. It could also represent a useful tool
for reducing adverse events, complications and patients’ discomfort,
however still not quantifiable.
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