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Table of Contents |
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Vol. 49, No. 5, 2015
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Issue release date: Published online first (Issue-in-Progress)
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| Section title: Original Paper |
Caries Res 2015;49:499-507
(DOI:10.1159/000438466)
Abstract
This study evaluated the effect of an experimental paste
containing hydroxyapatite in nanoparticles (nano-HA)/fluoride on dental
de-remineralisation in situ. Thirteen subjects took part in this
crossover/randomised/double-blind study performed in 4 phases (14 days
each). Four sound and 4 pre-demineralised specimens were worn
intraorally at each phase corresponding to the following treatments:
Nanop Plus (10% HA, 0.2% NaF, nano-HA/fluoride), MI Paste Plus (casein
phosphopeptide-amorphous calcium phosphate, 0.2% NaF), F (0.2% NaF) and
placebo. Two-hundred and forty enamel and 240 dentine specimens were
selected by using surface microhardness; half of them were subjected to
pre-demineralisation and the other half remained sound. Sound specimens
were further exposed to severe cariogenic challenge (20% sucrose in
biofilm) in situ, while pre-demineralised specimens were not. All
specimens were exposed to fluoride dentifrice slurry 2 × 1 min/day.
Thereafter, the treatments were done for 4 min. The de-remineralisation
was quantified by transversal microradiography. The data were
statistically analysed by repeated-measures ANOVA/Tukey's tests (p <
0.05). Generally, no huge differences were found among the treatments.
However, Nanop Plus was the only treatment able to significantly reduce
dentine demineralisation (ΔZ, integrated mineral loss) and to improve
enamel remineralisation (ΔΔZ, integrated mineral uptake) compared to
placebo. No treatments were able to reduce enamel demineralisation,
while for dentine remineralisation all treatments were similarly
effective in improving ΔΔZ compared to placebo. Nanop Plus seems to have
a positive influence on dental de-remineralisation, which should be
further confirmed.
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