Clinical efficacy of a bleaching enzyme-based toothpaste. A double-blind controlled clinical trial
Abstract
Objectives
To assess the efficacy of a bleaching enzyme-based toothpaste.
Material and methods
A
randomized clinical trial was carried out, comprising 48 participants
with teeth exhibiting color A3 or higher according to the Vita Classical
guide. One-half of the sample received the bleaching enzyme-based
toothpaste (White Kin®), while the other received placebo toothpaste.
Both products were supplied in identical containers and had the same
composition except for the active components. The teeth color was
measured with a spectrophotometer. The patients were instructed to brush
their teeth three times a day during three minutes with the assigned
product, during 12 weeks. The color measurements were repeated after 3,
6, 9 and 12 weeks of treatment. Color variation was based on the CIE
L*a*b* coordinates, ΔE and the EW index. The relationship of these
variables at different observation times were performed using a
generalized estimating equations model, which evaluated the effect of
treatment, time and interaction.
Results
The
patients using the bleaching enzyme-based toothpaste showed an increase
in lightness (80.14 -treatment- vs. 79.25 -control group-) and a
reduction in component b*. ΔE was found higher in the treatment group
(p = 0.064), close to statistical significance.
Conclusions
The
bleaching enzyme-based toothpaste could be potentially efficient in the
modification in tooth color progressing from the third to ninth week of
treatment, tending to stabilize after the ninth week
Clinical relevance
A
very low carbamide peroxide concentration, with the incorporation of
lactoperoxidase, tooth paste, tends to offer clinically satisfactory
results, in terms of modifications in tooth color, nevertheless no
significant differences were founded when compared to the control group,
with an oral hygiene controlled along the study.
Comments