Systemic antibiotics in the treatment of aggressive periodontitis. A systematic review and a Bayesian Network meta-analysis.

J Clin Periodontol. 2015 Jun 19. doi: 10.1111/jcpe.12427. [Epub ahead of print]



The aim of this study was to assess the effect of systemic antibiotic therapy on the treatment of aggressive periodontitis (AgP).


This study was conducted and reported in accordance with the PRISMA statement. The MEDLINE, EMBASE, and CENTRAL databases were searched up to June 2014 for randomized clinical trials comparing the treatment of subjects with AgP with either scaling and root planing (SRP) alone or associated with systemic antibiotics. Bayesian network meta-analysis was prepared using the Bayesian random-effects hierarchical models and the outcomes reported at 6-month post-treatment.


Out of 350 papers identified, 14 studies were eligible. Greater gain in clinical attachment (CA) (mean difference [MD]: 1.08 mm; p<0 .0001="" 0.45="" 0.53="" 1.05="" additional="" alone="" amoxicillin="" and="" antibiotics.="" associated="" bayesian="" benefits="" ca="" depth="" for="" gain="" in="" md:="" meta-analysis="" metronidazole="" mm="" mx="" network="" observed="" p="" pd="" placebo.="" probing="" reduction="" respectively="" showed="" srp="" systemic="" than="" tz="" was="" were="" when="" with="">


SRP plus systemic antibiotics led to an additional clinical effect compared with SRP alone in the treatment of AgP. Of the antibiotic protocols available for inclusion into the Bayesian network meta-analysis, Mtz and Mtz/Amx provided to the most beneficial outcomes. This article is protected by copyright. All rights reserved.


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