Abstract
AIM:
The
aim of this study was to assess the effect of systemic antibiotic
therapy on the treatment of aggressive periodontitis (AgP).
METHODS:
This
study was conducted and reported in accordance with the PRISMA
statement. The MEDLINE, EMBASE, and CENTRAL databases were searched up
to June 2014 for randomized clinical trials comparing the treatment of
subjects with AgP with either scaling and root planing (SRP) alone or
associated with systemic antibiotics. Bayesian network meta-analysis was
prepared using the Bayesian random-effects hierarchical models and the
outcomes reported at 6-month post-treatment.
RESULTS:
Out
of 350 papers identified, 14 studies were eligible. Greater gain in
clinical attachment (CA) (mean difference [MD]: 1.08 mm; p<0 .0001="" 0.45="" 0.53="" 1.05="" additional="" alone="" amoxicillin="" and="" antibiotics.="" associated="" bayesian="" benefits="" ca="" depth="" for="" gain="" in="" md:="" meta-analysis="" metronidazole="" mm="" mx="" network="" observed="" p="" pd="" placebo.="" probing="" reduction="" respectively="" showed="" srp="" systemic="" than="" tz="" was="" were="" when="" with="">
CONCLUSIONS:
SRP
plus systemic antibiotics led to an additional clinical effect compared
with SRP alone in the treatment of AgP. Of the antibiotic protocols
available for inclusion into the Bayesian network meta-analysis, Mtz and
Mtz/Amx provided to the most beneficial outcomes. This article is
protected by copyright. All rights reserved.
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