Formation of a hard tissue barrier after experimental pulp capping or partial pulpotomy in humans: an updated systematic review
International Endodontic Journal
Abstract
The aim was to update a systematic review of pulp capping and partial pulpotomy by Olsson et al.
(2006), by evaluating new evidence of formation of a hard tissue
barrier after pulp capping and partial pulpotomy of experimental
exposures in humans. PubMed (2005-01-01 to 2014-03-01) and CENTRAL were
searched using specific keywords. Hand searches were made and the level
of evidence for each included article was evaluated by the authors. The
evidence of the conclusions was graded as strong, moderately strong,
limited or insufficient. The initial search in PubMed yielded 215
abstracts. Hand searches of reference lists yielded no additional
original scientific articles. After a selection process and
interpretation, 22 articles were included and rated for level of
evidence: no article was rated as high and seven as moderate. Overall
the methodological quality of studies has improved since the previous
systematic review was published in 2006. The conclusions are that there
is limited scientific evidence that application of calcium hydroxide or
mineral trioxide aggregate to an exposed pulp frequently results in
formation of a hard tissue barrier, whereas adhesives or enamel matrix
derivatives do not. There is insufficient scientific evidence that
mineral trioxide aggregate promotes hard tissue formation more
frequently than calcium hydroxide.
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