The effects of periodontal treatment on diabetic patients: the DIAPERIO randomized controlled trial.

J Clin Periodontol. 2018 Aug 23. doi: 10.1111/jcpe.13003. [Epub ahead of print]

Abstract

AIM:

To assess whether periodontal treatment can lead to clinical, glycemic control and quality of life improvements in metabolically unbalanced diabetic patients (Type 1 or Type 2) diagnosed with periodontitis.

METHODS:

In this open-labeled randomized controlled trial, diabetic subjects (n=91) were given "immediate" or "delayed" periodontal treatment (full-mouth non-surgical scaling and root planing, systemic antibiotics, and oral health instructions). The main outcome was the effect on glycated hemoglobin (HbA_1C ) and fructosamine levels. The General Oral Health Assessment Index and the SF-36 index were used to assess quality of life (QoL).

RESULTS:

Periodontal health significantly improved after periodontal treatment (p<0 .001="" based="" be="" but="" control="" effects="" glycemic="" had="" hba="" no="" on="" periodontal="" safe="" seemed="" significant="" sub="" to="" treatment="">1C
(adjusted mean difference with a 95% confidence interval (aMD) of 0.04[-0.16;0.24]) and fructosamine levels (aMD 5.0[-10.2;20.2]). There was no obvious evidence of improvement in general QoL after periodontal treatment. However, there was significant improvement in oral health-related QoL (aMD 7.0[2.4;11.6], p=0.003).

CONCLUSION:

Although periodontal treatment showed no clinical effect on glycemic control in this trial, important data was provided to support periodontal care among diabetic patients. Periodontal treatment is safe and improves oral health-related QoL in patients living with diabetes. ISRCTN15334496. This article is protected by copyright. All rights reserved.