Ozone application as adjunctive therapy in chronic periodontitis: Clinical, microbiological and biochemical aspects
Abstract
Background/purpose
The application of ozone as an adjunctive treatment represents a new approach in the management of chronic periodontitis.
The purpose of this study was to evaluate the clinical, biochemical and
microbiological efficacy of ozone treatment as an adjunct to scaling and root planing (SRP) in generalized chronic periodontitis (GCP) patients.
Materials and methods
Eighteen
patients (9 males and 9 females; aged from 28 to 47 years, mean age of
40 ± 6.51 years) with GCP were recruited in the study. In a split mouth
design, two quadrants in each patient were randomly allocated to
SRP-alone or SRP-ozone therapy (SRP + OT) groups by coin toss method.
Subgingival plaque and gingival
crevicular fluid (GCF) samples were collected at baseline, following
1st and 3rd months. The clinical parameters were monitored at baseline
and after 3 months. Microbiological parameters were analyzed by
quantitative-PCR and GCF biomarkers were determined by ELISA. Results were analyzed statistically.
Results
Statistically
significant improvements in all clinical parameters were accompanied by
a reduction in microbiological and biochemical parameters in both
treatment groups. SRP treatment resulted in a significant reduction of Porphyromonas gingivalis (Pg) at 1st month and Tannerella forsythia (Tf) and Prevotella intermedia (Pi) at 3 months. Following SRP treatment the interleukin
(IL)-8 levels were significantly reduced at month 1. There were no
significant differences between two treatments for any of the
parameters.
Conclusion
Within
the limitations of this study, adjunctive ozone therapy did not provide
additional benefits to clinical, microbiological and biochemical
parameters over SRP in chronic periodontitis patients.
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