In vitro study of the effects of fluoride-releasing dental materials on remineralization in an enamel erosion model

Journal of Dentistry



This study was conducted to compare the remineralization effects of five regimens on the loss of fluorescence intensity, surface microhardness, roughness and microstructure of bovine enamel after remineralization. We hope that these results can provide some basis for the clinical application of these materials.


One hundred bovine incisors were prepared and divided into the following five groups, which were treated with distinct dental materials: (1) Clinpro™ XT varnish(CV), (2) F-varnish(FV), (3) Tooth Mousse(TM), (4) Fuji ? LC® light-cured glass ionomer pit and fissure sealant(FJ), and (5) Base Cement® glass polyalkenoate cement(BC). Subsequently, they were detected using four different methods: quantitative light-induced fluorescence, microhardness, surface 3D topography and scanning electron microscopy.


The loss of fluorescence intensity of CV, BC and FJ groups showed significant decreases after remineralization (p < 0.05). The microhardness values of the BC group were significantly higher than those of the other groups (p < 0.05) after 6 weeks of remineralization. The CV group's surface roughness was significantly lower than those of the other groups after 6 weeks of remineralization (p < 0.05). Regarding microstructure values, the FV group showed many round particles deposited in the bovine enamel after remineralization. However, the other four groups mainly showed needle-like crystals.


GIC-based dental materials can promote more remineralization of the artificial enamel lesions than can NaF-based dental materials. Resin-modified GIC materials (e.g., CV and FJ) have the potential for more controlled and sustained release of remineralized agents. The effect of TM requires further study.


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