Abstract
Background
Taste
disorder is a frequent drug-induced or disease-related oral trouble.
Various pharmacological, surgical, or physical treatments have
previously been proposed for taste function recovery.
Objectives
The
aim of the present systematic review was to assess the effects of
palliative and curative interventions on taste recovery in light of
recent literature.
Materials and methods
In
accordance with the Preferred Reporting Items for Systematic Reviews
and Meta-Analyses (PRISMA) statement, a search of the literature
published up to June 2019 was conducted using MEDLINE via PubMed,
EMBASE, and The US National Institutes of Health Trials Register
(PROSPERO registration reference: CRD 42019139315). The methodological
quality of the included trials was rated with the “Delphi list For
Quality Assessment of Randomized Clinical Trials” and the
Newcastle-Ottawa scale.
Results
From
the 1842 titles first identified, 28 articles met the inclusion
criteria. Interventions included zinc (aspartate, sulfate, gluconate,
acetate, picolinate, and Polaprezinc®), esomeprazole, l-thyroxin, bethanechol, oral glutamine, delta-9-tetrahydrocannabinol, alpha-lipoic acid, Ginkgo biloba, artificial saliva, pilocarpine, local anesthesia, and improved oral hygiene. The quality of evidence ranged from poor to high.
Conclusion
Improving
oral hygiene may promote taste ability. Zinc may prevent and alleviate
taste disorder in patients undergoing head and neck radiotherapy.
Clinical relevance
The
systematic review provided evidence about the clinical efficacy of oral
procedures, zinc supplementation, and palliative cares in dysgeusic
patients. Further research is needed to find effective treatments with
low adverse effects.
Comments