J Clin Periodontol. 2018 Dec 8. doi: 10.1111/jcpe.13044. [Epub ahead of print]
Abstract
AIM:
This
systematic review aimed to evaluate the impact of diabetes mellitus on
clinical outcomes of non-surgical periodontal therapy.
MATERIALS AND METHODS:
Searches
were conducted in electronic databases to screen studies published from
January 1960 to August 2018. The included studies had at least two
groups of patients: chronic periodontitis only (P) or both diabetes and
chronic periodontitis (DMP). Outcomes of interest included the
difference between the two groups in probing depth (PD) reduction and
clinical attachment level (CAL) gain following non-surgical periodontal
therapy. Meta-regression was conducted to evaluate the correlation
between the outcomes of interest and contributing factors.
RESULTS:
A
total of 12 studies with a follow-up period up to 6 months were
included. There was no significant difference in PD reduction (p=0.55)
or CAL gain (p=0.65) between the two groups. A positive association
between PD reduction and baseline PD difference (p=0.03), and a negative
association between PD reduction and age (p=0.04) were found. The level
of HbA1c at baseline did not significantly affect the difference in PD
reduction (p=0.39) or CAL gain (p=0.44) between two groups.
CONCLUSIONS:
Recognizing
the study's limitations, we conclude that diabetes mellitus (HbA1c
≤8.5%) does not appear to significantly affect short-term clinical
periodontal outcomes of non-surgical periodontal treatment. This article
is protected by copyright. All rights reserved.
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