Plasma rich in growth factors had limited effect on early bone formation in extraction sockets
, , , , . Plasma rich in growth factors had limited effect on early bone formation in extraction sockets. Clin. Oral Impl. Res. 00, 2013, 1–3
Abstract
Aim
To address the criticisms raised by Anitua et al. (European Journal of Oral Implantology, 6, 2013, 9–11) to the article “Plasma Rich in Growth Factors (PRGF) in Human Post-Extraction Sockets: an Histological and Histomorphometric Study.”, recently published by Farina and colleagues (Clinical Oral Implants Research 2012; doi: 10.1111/clr.12033).
Methods
All
the methodological aspects criticized in the letter by Anitua et al.
were thoroughly reconsidered and discussed in a structured short
communication. When indicated, pertinent, additional material was
included to reinforce our considerations.
Results
As
most clinical studies in implant dentistry, including previous studies
evaluating the efficacy/effectiveness of PRGF, the study by Farina
et al. has some limitations. However, it is currently the only published
controlled trial using quantitative parameters related to PRGF-induced
early bone formation.
Conclusions
Despite
all limitations, the results of the study by Farina et al., which were
based on different quantitative parameters (micro-CT scan,
immunohistochemical markers of wound healing and bone deposition),
indicated a limited effect of PRGF on early bone formation in extraction
sockets.
Comments