Minerva Stomatol. 2017 Oct 31. doi: 10.23736/S0026-4970.17.04084-5. [Epub ahead of print]
Abstract
BACKGROUND:
This
randomized clinical trial evaluated the clinical and microbiological
effects of 0.147% ethyl lauroyl arginate (LAE)-containing mouthwash
compared to 0.12% chlorhexidine (CHX) mouthwash in the treatment of
periodontitis.
MATERIALS AND METHODS:
Subjects
were randomized to use 0.147% LAE and 0.12% CHX mouthwash after
professional mechanical plaque removal (PMPR) twice daily 1 hour after
brushing for 4 weeks. Periodontal pocket depth (PPD), bleeding on
probing (FMBS) and dental plaque (FMPS) were measured at baseline, 4
weeks and 3 months. Microbiological samples were taken at baseline, at 4
weeks and 3 months after plaque recording and prior to PPD and BoP
measurements.
RESULTS:
Forty
subjects were randomized to treatment. Both therapies resulted in
reduced FMPS, FMBS and residual pockets at 4 weeks and 3 months. The
differences were not statistically significant. There were no
treatment-related adverse events. Total bacterial count and the specific
pathogens were reduced at 4 weeks and 3 months by both mouthwashes with
no statistical differences between them at neither periods of time.
CONCLUSIONS:
0.147%
LAE-containing mouthwash could be an alternative to the use of 0.12%
CHX in the non surgical therapy of periodontitis considering the similar
clinical effects, more stable microbiological improvement and absence
of adverse effects.
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