In vivo bisphenol-A release from dental pit and fissure sealants: A Systematic Review
Available online 1 May 2013
Abstract
Objective
To
search the literature and assess the short- and long- term release of
bisphenol-a (BPA) in human tissues after treatment with dental sealants.
Data
Two
review authors performed data extraction independently and in duplicate
using data collection forms. Disagreements were resolved by discussion
with an arbiter.
Sources
Electronic
database searches of published and unpublished literature were
performed. The following electronic databases with no language and
publication date restrictions were searched: MEDLINE (via Ovid and
Pubmed), EMBASE (via ovid), Cochrane Trials Register and CENTRAL. The
reference lists of all eligible studies were hand-searched.
Study selection
In the absence of RCTs, six interventional and two observational studies, examining in vivo
BPA release in human salivary, blood and urinary samples, were
included. Due to the heterogeneity in methodology and reporting the main
synthesis of the results was qualitative. The quantitative synthesis
based on the weighted Z-test could only include two studies. BPA levels
identified in saliva ranged from traces below the method's detection
limit to 30 μg/ml. In urine, BPA quantities spanned from 0.17 mg/g to
45.4 mg/g. BPA was not traced in any blood sample at any point of time
in the relevant studies. The quantitative analysis showed evidence of
BPA release one hour after sealant placement compared to the amount
traced before restoration (Stouffer's z trend: <0 .001="" p="">
Conclusions
The
available evidence on this topic derived from studies that represent a
moderate level of evidence. Nevertheless, the available evidence
supports that BPA is released in saliva after sealant placement.
Comments