Kavo Licenses DIFOTI

Electro-Optical Sciences, Inc.
(“EOS”) [NASDAQ: MELA], today announced that it has signed an exclusive
licensing agreement with KaVo Dental GmbH (“KaVo”), a leading dental
equipment manufacturer, to further develop and commercialize DIFOTI ® , a U.S.
Food and Drug Administration-cleared non-invasive imaging device developed by
EOS for the detection of dental caries.

In accordance with the terms of the agreement, KaVo will pay EOS an
undisclosed upfront sum as well as up to a double digit annual royalty based on
the number of systems sold per calendar year. KaVo has made a multi-million
dollar commitment to refine the DIFOTI product for commercial launch.