Tuesday, August 24, 2010

Erosion-inhibiting potential of a stannous chloride-containing fluoride solution under acid flow conditions in vitro

 Archives of Oral Biology
Volume 55, Issue 9, Pages 702-705 (September 2010)

Abstract 

Objectives
This study aimed to analyse the erosion-inhibiting potential of a single application of stannous chloride-containing fluoride solution on pellicle-covered enamel and dentine under constant acid flow conditions in vitro.
Design
Bovine enamel (n=60) and dentine (n=60) samples were exposed 1h to the oral cavity of 4 healthy volunteers to allow for in situ pellicle formation. Pellicle-covered samples were randomly assigned to three groups (each n=20 enamel and n=20 dentine samples; 5 enamel and 5 dentine samples/volunteer) and treated once with a SnCl2/AmF/NaF (800ppm Sn(II), 500ppm F, pH 4.5) or a NaF solution (500ppm F, pH 4.5) for 2min or remained untreated (controls). Samples were eroded with hydrochloric acid (pH 2.6) in a small erosion chamber at 60μl/min for 25min. Calcium release into the acid was monitored in consecutive 30s intervals for 5min, then at 1min intervals up to a total erosion time of 25min using the Arsenazo III procedure. Data were statistically analysed by random-effects linear models (p<0.05).
Results
The stannous chloride-containing fluoride solution reduced calcium loss of enamel and dentine to up to 6min and 3.5min, respectively. Calcium loss (% of control) amounted from 24±7 (30s) up to 93±14 (6min) in enamel and from 38±13 (30s) to 87±15 (3.5min) in dentine. The sodium fluoride solution was unable to reduce enamel and dentine erosion at any time point.
Conclusion
A single application of a stannous chloride-containing fluoride solution reduced enamel and dentine erosion up to 6min and 3.5min of constant acid flow, respectively.

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