Professor's discovery offers a lifetime of cavity protection

Working in his research lab in 1976, Dr. Jeffrey Hillman accidentally discovered a mutant strain of Streptococcus mutans, the bacteria that causes tooth decay. Unlike typical Streptococcus mutans, this strain was lactose-deficient, meaning that after it gorged on sugar, it didn’t produce copious amounts of lactose acid, the stuff that digs holes in tooth enamel.

Hillman, a dentist and professor of oral biology at the University of Florida’s College of Dentistry, immediately recognized the potential of this newfound strain: No more cavities. No more drills.

After years of clinical trials, first on rats and now on people, Hillman’s treatment is moving closer to market. Called Replacement Therapy, it essentially replaces the Streptococcus mutans already in the mouth with a modified, lactose-deficient strain. “It may take six months to a year, but eventually our strain will kick out the disease-causing strain,” he says. “A one-time treatment can give lifetime protection.”

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