Regenerative Endodontic Procedures with Minced Pulp Tissue Graft in Mature Permanent Teeth: A Clinical study
Journal of Endodontics Publication History: Received May 22, 2024; Revised August 21, 2024; Accepted October 5, 2024; Published online October 12, 2024 Abstract Introduction Regenerative endodontic procedures (REPs) using cell-based approaches have emerged as novel treatment modalities. This clinical study aimed to present the outcomes and explore factors influencing REPs with minced pulp tissue (MP) grafts in a mature tooth. Methods: Six healthy male patients aged 20-27 requiring non-surgical root canal treatment were enrolled in this study. MP tissue obtained from third molars was introduced into the instrumented, disinfected, and blood-filled root canal. The canal was sealed with bioceramic cement, and the coronal access cavity was restored. Results: Follow-ups for six cases ranged from 19 to 42 months. Radiographically, all the teeth showed favorable outcomes. Among the six teeth, two showed neither intracanal calcification nor recovery in sensibility tests, and one had
