Wednesday, December 15, 2010

HPV Link Between Cervical and Oral Cancer

Detection of human papilloma virus (HPV) in oral mucosa of women with cervical lesions and their relation to oral sex practices

Source: 7thspace.com
Authors: Luis Sanchez-Vargas et al
Previous studies have either investigated the relationship of HPV with oral cancer or the prevalence of HPV on the oral cavity. The purpose of this investigation was to study the prevalence of HPV in oral cavity of women with oral sex practices and cervical lesions.
Methods:
Forty six (46) non-smokers and non-alcoholic patients attended the “Clinica de Displasias”of “Ciudad Juarez”were sampled. This population had a CIN (cervical intraepithelial neoplasia) diagnosis sometime between the previous six months. On previous consent they filled out a questionnaire related to their oral sex practices. Afterwards one swab from cheeks and another from palate/gum were taken; PCR (polymerase chain reaction) was used to determine generic HPV, HPV16 and HPV18.
Results:
Seventy two percent (72%) of the patients stated to have oral sex practices regularly which all of them were positive to HPV either in oral mucus, palate/gum or both. The total of the given results showed that 35% had HPV16; among those distributed in 26% with regular oral sex practices and 9% stated as never practiced oral sex.
An association was found between oral HPV16 positivity and progression to CIN advanced lesions. On the other hand HPV18 was not detected. The frequency of HPV16 was higher in buccal mucosa (23%) versus palate/gum (16%).
Conclusions:
This study suggests that buccal HPV16 infection is associated with CIN progression.
Source: Infectious Agents and Cancer 2010, 5:25
Authors: Luis Sanchez-Vargas, Cecilia Diaz-Hernandez, Alejandro Martinez-Martinez

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